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  1. Suppositories were used by patients to get the very least about 5 days on the first day of the treatment; after that interval how long does it take for diflucan to work they might be changed to an oral drug. It can be taken anytime, anywhere, and it starts to relieve your symptoms in just one day. Depending on the severity of the infection Diflucan can be prescribed as a single dose, as a series of doses taken every three days, or as a daily medication taken for ten to fourteen days.